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Abnormal results of investigations (e.g., laboratory studies of blood camples) were the most common adverse event, followed by cardiac disorders and nervous system disorders. Of patients treated with T-DM1, 9 experienced abnormal results of investigations, 5 experienced cardiac disorders, and 4 experienced nervous system disorders. Five cases each of abnormal results of investigations and cardiac disorders were present in the trastuzumab group, with no nervous system disorders occurring in this group. Seven-year invasive-disease-free survival and seven-year overall survival rates in the immunohistochemistry (IHC) 2+ subgroup were 72.4% and 83.3% on T-DM1. “These findings warrant evaluation of additional or alternative therapies to improve outcomes for these patients, including those who had initially presented with inoperable disease, those with positive axillary nodes after neoadjuvant therapy, and those with both IHC 2+ and ISH-amplified disease,” said researchers. Discontinuation of trial enrollment due to an invasive disease event or death occurred in 105 patients (14.1%) in the T-DM1 group and 159 patients (21.4%) in the trastuzumab group. Additionally, prior discontinuation occurred in 117 patients (15.7%) and 123 patients (16.6%), respectively. The addition of inavolisib (Itovebi) to palbociclib (Ibrance) and fulvestrant (Faslodex) demonstrated a statistically significant and clinically meaningful improvement in overall survival (OS) compared to palbociclib and fulvestrant alone for patients with PIK3CA-mutated, HR-positive, HER2-negative locally advanced or metastatic breast cancer, which met the key secondary end point of the phase 3 INAVO120 study (NCT04191499). These data reinforce the regimen’s efficacy in the frontline, as established by previously reported data from INAVO120. In the primary analysis, patients treated with inavolisib plus palbociclib and fulvestrant achieved a median progression-free survival (PFS) of 15.0 months (95% CI, 11.3-20.5) vs 7.3 months (95% CI, 5.6-9.3) with placebo plus palbociclib and fulvestrant.2This translated to a 57% reduction in the risk of disease worsening or death (HR, 0.43; 95% CI, 0.32-0.59; P < .001).1The overall response rate (ORR) in the experimental arm was 58% (95% CI, 50%-66%) vs 25% (95% CI, 19%-32%) in the placebo arm, and the median duration of response (DOR) was 18.4 months (95% CI, 10.4-22.2) vs 9.6 months (95% CI, 7.4-16.6) in these respective groups.2 Notably, although OS data were immature at the time of the primary analysis, a trend in favor of the inavolisib regimen was observed (HR, 0.64; 95% CI, 0.43-0.97; P = .0338) https://www.mixily.com/listing/4427264015219031527 https://www.mixily.com/listing/3849001469549159802 https://www.mixily.com/listing/2663240702286993000 https://www.mixily.com/listing/6187179237921868416 https://www.mixily.com/listing/1651038323725727797 https://www.mixily.com/listing/354113218320916205 https://www.mixily.com/listing/2468966878633555565 https://www.mixily.com/listing/1096741103818406968 https://www.mixily.com/listing/1042722939345470253 https://www.mixily.com/listing/4855941210084616905 https://www.mixily.com/listing/8050947916365056586 https://www.mixily.com/listing/1968468669654356536 https://www.mixily.com/listing/7150206081449302797 https://www.mixily.com/listing/364950383213939729 https://www.mixily.com/listing/5856736570674671561 https://www.mixily.com/listing/1689760062273465652 https://www.mixily.com/listing/1473094946093936802 https://www.mixily.com/listing/2934052174930952341 https://www.mixily.com/listing/2739296415184286339 https://www.mixily.com/listing/6892361991941964274 https://www.ypchina.org/conglay-patients-treated-with-gedebug-caubon/ https://thetaxtalk.com/questions-2/question/kinoongcua-established-by-previously-molorges/ https://all4.vip/p/page/view-persons-profile?id=64117 https://papaly.com/categories/share?id=481414f745f144168932d02159fb7f38 https://www.myvipon.com/post/1530360/Muncangarab-Download-Latest-Version-Kolopos-2025-amazon-coupons

Regimen not only delayed disease progression, but also helped people with advanced hormone receptor–positive, PIK3CA-mutated breast cancer live longer,” Levi Garraway, MD, PhD, Roche’s chief medical officer and head of Global Product Development, stated in a news release.1 “These findings underscore our ambition to improve survival rates for people with breast cancer. The [inavolisib]-based regimen has the potential to become the new standard of care for these patients.” The randomized, double-blind, placebo-controlled trial enrolled 325 adult patients with endocrine resistant, PIK3CA-mutated, hormone receptor–positive, HER2-negative breast cancer that was locally advanced or metastatic.2 Patients were required to have experienced disease progression during or within 12 months of completing adjuvant endocrine therapy. Prior receipt of systemic therapy for locally advanced or metastatic disease was not permitted. Upon enrollment, patients were randomly assigned 1:1 to receive either 9 mg of oral inavolisib or placebo once daily during a 28-day cycle. This was administered alongside 125 mg of daily palbociclib for 21 days per cycle and 500 mg of fulvestrant administered intramuscularly on days 1 and 15 of cycle 1, and day 1 of each subsequent cycle. Treatment continued until disease progression or unacceptable toxicity. Stratification factors included the presence of visceral disease (yes vs no), endocrine resistance (primary vs secondary), and geographic region (North America/Western Europe vs Asia vs other). The study’s primary end point was investigator-assessed PFS per RECIST 1.1 criteria. Secondary efficacy end points comprised OS, investigator-assessed ORR, and DOR. The most common adverse effects reported in at least 20% of patients treated with the inavolisib-based regimen were decreased neutrophils, decreased hemoglobin, increased fasting glucose, decreased platelets, decreased lymphocytes, stomatitis, diarrhea, decreased calcium, fatigue, decreased potassium, increased creatinine, increased alanine aminotransferase levels, nausea, decreased sodium, decreased magnesium, rash, decreased appetite, COVID-19 infection, and headache. In the updated OS analysis, no new safety signals were observed.1 Ongoing Evaluation of Inavolisib In addition to INAVO120, 3 phase 3 trials evaluating inavolisib-based combinations in patients with PIK3CA-mutated locally advanced or metastatic breast cancer are being conducted.1 These include the INAVO121 trial (NCT05646862), which is evaluating the agent in combination with fulvestrant vs alpelisib (Piqray) plus fulvestrant in hormone receptor–positive, HER2-negative breast cancer following progression on a CDK4/6 inhibitor and endocrine therapy; the INAVO122 study (NCT05894239) investigating inavolisib plus a subcutaneous fixed dose of pertuzumab (Perjeta) and trastuzumab (Herceptin) as maintenance therapy in HER2-positive disease; and the INAVO123 study (NCT06790693) evaluating first-line inavolisib plus a CDK4/6 inhibitor and letrozole in endocrine-sensitive, PIK3CA-mutated hormone receptor–positive, HER2-negative breast cancer. visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb visitweb

The Eiffel Tower was an ideal structure for taking these measurements and scientists have used these records to infer smoke pollution levels in the French capital in the 1890s. But these records are not directly comparable to those made today. The closest equivalent is data on levels of particulates: microscopic particles released by burning fossil fuels and from traffic exhausts. Exposure to particulate pollution is extremely harmful to health and responsible for the vast majority of air pollution-related deaths. Heat could be a killer if you aren't able to get your nutrition and hydration right – Pragnya Mohan Particulate levels in 1920s Paris may well have been about 100 micrograms per cubic metre, estimates Giles Harrison, professor of atmospheric physics at the University of Reading in the UK. This is about five times higher than pollution levels today, BBC analysis reveals. The main sources of Parisian pollution in 1924 were coal-powered factories and domestic heating as well as motor vehicles, says Harrison. The 1924 Stade de Colombes Olympic stadium, located in north-west Paris, was surrounded by factories, says Catherine Radtka, a historian of science at the French National Conservatory of Arts and Crafts. "There were tyre factories, sugar and alcohol refineries and gas plants in the area, emitting fumes, dust and noxious gases," says Radtka. "There were already complaints from farmers at the beginning of the 20th Century…they said the fumes were destroying their crops." Physicians had also started sounding the alarm about the health risks of air pollution, she says. Iconic landmarks, such as the Notre Dame, were caked in thick, black dust. "Everything was black in Paris because of the smog," says Radtka. In 2023, by contrast, monthly levels of large particulates (PM10) in the city averaged 19 micrograms per cubic metre of air – a five-fold reduction compared with 1924. Much of this improvement has occurred relatively recently. In 2003, monthly PM10 levels still averaged 67 micrograms per cubic metre, but air quality improved in the decades since as the city has prioritised cyclists and pedestrians over cars. Levels of the smallest, most dangerous particles, measuring less than 2.5 microns across (known as PM2.5), have fallen by similar proportions since 2003. "Cars will be very restricted in the centre of Paris during the Olympics," says Safieddine. "I don't think pollution will be a problem unless we have high temperatures. Heatwaves are often associated with pollution events." Mohan says her bigger concern is polluted water in the River Seine. The river failed water quality tests a month before the start of the games due to high levels of E. coli. But organisers say that the Seine is safe to swim in, with Paris mayor Anne Hidalgo and other members of the Olympic committee going in for a dip in mid-July to prove that the water is clean. (Read about the efforts to tackle the Seine's historic pollution.) Mohan hopes to swim in the Seine at the Paris Games. "Growing up, I never got to swim in my own river in Ahmedabad because it was so polluted," she says. "It's scary that in future the triathlon might not be an outdoor sport due to climate change." Extreme heat is already changing her sport. Mohan says she can no longer train outdoors in India due to the scorching temperatures. This reality has forced her to move away from her home and train in London instead. The conditions faced by the cross-country runners in the 1924 Olympics are becoming increasingly common for athletes. Mohan has competed in temperatures exceeding 40C (104F) and 50-80% humidity. "If I had a choice, I wouldn't have done those races," she says. "But as athletes we are wired to perform our best and to keep pushing ourselves." -- The graphs in this story were created by Diana Mota. For essential climate news and hopeful developments to your inbox, sign up to the Future Earth newsletter, while The Essential List delivers a handpicked selection of features and insights twice a week. For more science, technology, environment and health stories from the BBC, follow us on Facebook and X. Security forces in Venezuela have fired tear gas and rubber bullets at people protesting Sunday’s disputed election result. Thousands of people descended on central Caracas on Monday evening, some walking for miles from slums on the mountains surrounding the city, towards the presidential palace. Protests erupted in the Venezuelan capital the day after President Nicolás Maduro claimed victory. The opposition has disputed Mr Maduro's declaration as fraudulent, saying that after reviewing 73.2% of the voting tallies, it was clear that its candidate, Edmundo González, had won convincingly. Opinion polls ahead of the election suggested a clear victory for the challenger. Opposition parties had united behind Mr González in an attempt to unseat President Maduro after 11 years in power, amid widespread discontent over the country's economic crisis. Choreographed celebrations but opposition demands proof A heavy military and police presence was on the streets of Caracas with the aim of trying to disperse protesters and prevent them from approaching the presidential palace. Crowds of people chanted “freedom, freedom!” and called for the government to fall. Footage showed tyres burning on highways and large numbers of people on the streets, with police on motorbikes firing tear gas. In some areas, posters of President Maduro were ripped down and burned while tyres, cars and rubbish were also set alight. Armed police, military and left-wing paramilitaries who are sympathetic to the government clashed with protesters and blocked off many roads around the city centre. Venezuela's government also announced a temporary suspension of commercial air flights to and from Venezuela with Panama and the Dominican Republic starting from 20:00 local time on Wednesday. In a speech on Venezuelan state television, Mr Maduro said it is his "obligation to tell you the truth". "We are all under the obligation to listen the truth, to gear up with patience, calmness and strength because we are familiar with this movie and we know how to face these situations and how to defeat the violent.” visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit visit

lower rates of Bifidobacterium-positive proximal colon cancers. Proximal colon cancer is a type of colon cancer that occurs on the right side of the colon and can have worse survival outcomes than cancers that occur in the distal colon, which is on the left side. Ugai says the bacteria in yogurt appear to promote an overall healthy balance of bacteria in the gut. And that, in turn, promotes a strong and healthy gut barrier, which is important, because when the gut barrier becomes too permeable, it can lead to inflammation and increase the risk of colon cancer. "My message is, if you like yogurt, go for it," Ugai says. The findings are in line with prior studies that have linked yogurt intake to a lower risk of colon cancer, says Dr. Chris Damman, a gastroenterologist and professor at the University of Washington who studies the intersection of the microbiome and metabolic disease. Yogurt is a fermented food, meaning it is produced when microbes break down sugars in foods in a way that produces complex flavors and prevents them from spoiling. One randomized controlled trial found that people assigned to eat a diet rich in yogurt and other fermented foods — such as kefir, fermented cottage cheese, kimchi and kombucha tea — for 10 weeks had lower markers of inflammation and improved diversity of microbes in their gut. Damman says that along with fiber, healthy fats and nutrients known as polyphenols found in plant-based foods, yogurt and other fermented foods are a staple of a healthy gut. "These are the common denominators across culinary traditions and healthy eating," he says. From Middle Eastern cream cheese-like labneh to Persian abdoogh khiar soup and Indian raita, cultures around the world have long embraced yogurt as a culinary staple. But before adding yogurt to your diet be sure to check the nutrition label. Research has found that, despite its health halo, many yogurts can be loaded with added sugar. Your best bet is to stick with yogurts without added sugar. Add some berries, bananas or other fruit if you miss that hint of sweetness. Heat compromises blood flow to the gut and leads to excessive sweating, which can cause dehydration, cramping, exhaustion and fainting. Muscle glycogen, the body's stored form of glucose, is used up more quickly when it is hot, impairing endurance performance, says Tipton. At his annual Super Bowl news conference Monday, NFL commissioner Roger Goodell strongly supported the league’s policies designed to promote diversity at the club-employment level and said they would continue. But during Super Bowl LIX, and with President Donald Trump apparently planning to attend on Sunday, the NFL might be making another kind of statement on the Caesars Superdome field itself. According to two league sources, who spoke on condition of anonymity because of the sensitivity of the discussions, league officials recently changed one of the slogans expected to be stenciled in the back of an end zone from “End Racism” to “Choose Love.” The game between the Kansas City Chiefs and the Philadelphia Eagles will mark the first time since February 2021 that “End Racism” is not included as a message in the back of a Super Bowl end zone. The switch, conveyed internally to high-level employees earlier this week, could be perceived as a nod to the current political climate. Following the lead of Trump, who was inaugurated last month, many corporations and institutions are abandoning their diversity, equity and inclusion programs. Goodell did not follow suit when asked about the league’s policies on Monday, saying he was “proud” of the league’s diversity efforts. “We got into diversity efforts because we felt it was the right thing for the National Football League,” Goodell said. “And we’re going to continue those efforts, because we’ve not only convinced ourselves we’ve proven it to ourselves — it does make the NFL better.” The decision to do away with “End Racism” as a slogan led at least one high-ranking league official to express concern in light of Trump’s public statements on the subject. But NFL spokesperson Brian McCarthy said that the decision was based on sensitivity to recent tragedies, including the terrorist attack in New Orleans’ French Quarter in January, the deadly wildfires in the Los Angeles area and the fatal air collision near Reagan National Airport near Washington, D.C. “It Takes All of Us” will also appear in the end zone for this year’s Super Bowl. “We felt it was an appropriate statement for what the country has collectively endured, given recent tragedies, and can serve as an inspiration,” said McCarthy, who noted that “Choose Love” and “It Takes All of Us” also appeared in the end zones for this year’s AFC Championship Game in Kansas City. The NFC Championship Game in Philadelphia included “End Racism” as an end-zone slogan. League sources also indicated that Trump is expected to attend Sunday’s game as a guest of New Orleans Saints owner Gayle Benson. The NFL launched its “Inspire Change” platform in 2018. Two years later, slogans such as “End Racism,” “It Takes All of Us,” “Stop Hate,” “Choose Love” and “Vote” began appearing on end-zone borders, part of a broader, multi-pronged effort to promote diversity and inclusion. In an internal memo at the time, the messages were said to demonstrate “how football and the NFL brings people together to work as one and use our example and our actions to help conquer racism.” The changes were initiated in the wake of the murder of George Floyd, an unarmed Black man, by a Minneapolis police officer, sparking nationwide protests against police brutality. The issue had risen to the forefront of the NFL community four years earlier, when then-San Francisco 49ers quarterback Colin Kaepernick began kneeling during the national anthem, and other players around the league soon followed. t's not just athletes' physical performance that is diminished by heat, he adds. "Heat changes your cognitive function in terms of complex decision making, makes you more irritable and more agitated, reduces motivation, and decreases mood." This means that scorching temperatures can also impact more "passive sporting events'', such as archery or shooting, where the "margins of error are very small", he says. (Read more about the sinister ways heatwaves warp the mind.) Acclimatising to high temperatures is now a critical part of training for athletes, says Tipton. "If you get your heat preparation wrong, it's a risk to life and limb." Medal Moments Want to read more about the Olympics? Sign up for Medal Moments, your free global guide to Paris 2024, delivered daily to your inbox throughout the Games. Mohan is preparing for high temperatures at the Paris Olympics by spending up to an hour in saunas several times a week and turning off the fans while doing her indoor cycling training. более более более более более более более более более более более более более более более более более более более более более более более более более более более более более news news news news

Tomotaka Ugai, a co-senior author of the study. He's an investigator at Brigham and Women's Hospital and a department associate at the Harvard T.H. Chan School of Public Health. Specifically, the researchers found that the habitual yogurt eaters had lower rates of Bifidobacterium-positive proximal colon cancers. Proximal colon cancer is a type of colon cancer that occurs on the right side of the colon and can have worse survival outcomes than cancers that occur in the distal colon, which is on the left side. Ugai says the bacteria in yogurt appear to promote an overall healthy balance of bacteria in the gut. And that, in turn, promotes a strong and healthy gut barrier, which is important, because when the gut barrier becomes too permeable, it can lead to inflammation and increase the risk of colon cancer. "My message is, if you like yogurt, go for it," Ugai says. The findings are in line with prior studies that have linked yogurt intake to a lower risk of colon cancer, says Dr. Chris Damman, a gastroenterologist and professor at the University of Washington who studies the intersection of the microbiome and metabolic disease. Yogurt is a fermented food, meaning it is produced when microbes break down sugars in foods in a way that produces complex flavors and prevents them from spoiling. One randomized controlled trial found that people assigned to eat a diet rich in yogurt and other fermented foods — such as kefir, fermented cottage cheese, kimchi and kombucha tea — for 10 weeks had lower markers of inflammation and improved diversity of microbes in their gut. Damman says that along with fiber, healthy fats and nutrients known as polyphenols found in plant-based foods, yogurt and other fermented foods are a staple of a healthy gut. "These are the common denominators across culinary traditions and healthy eating," he says. From Middle Eastern cream cheese-like labneh to Persian abdoogh khiar soup and Indian raita, cultures around the world have long embraced yogurt as a culinary staple. But before adding yogurt to your diet be sure to check the nutrition label. Research has found that, despite its health halo, many yogurts can be loaded with added sugar. Your best bet is to stick with yogurts without added sugar. Add some berries, bananas or other fruit if you miss that hint of sweetness. Heat compromises blood flow to the gut and leads to excessive sweating, which can cause dehydration, cramping, exhaustion and fainting. Muscle glycogen, the body's stored form of glucose, is used up more quickly when it is hot, impairing endurance performance, says Tipton. At his annual Super Bowl news conference Monday, NFL commissioner Roger Goodell strongly supported the league’s policies designed to promote diversity at the club-employment level and said they would continue. news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news news

Bacteria in yogurt appear to promote an overall healthy balance of bacteria in the gut. And that, in turn, promotes a strong and healthy gut barrier, which is important, because when the gut barrier becomes too permeable, it can lead to inflammation and increase the risk of colon cancer. "My message is, if you like yogurt, go for it," Ugai says. The findings are in line with prior studies that have linked yogurt intake to a lower risk of colon cancer, says Dr. Chris Damman, a gastroenterologist and professor at the University of Washington who studies the intersection of the microbiome and metabolic disease. Yogurt is a fermented food, meaning it is produced when microbes break down sugars in foods in a way that produces complex flavors and prevents them from spoiling. One randomized controlled trial found that people assigned to eat a diet rich in yogurt and other fermented foods — such as kefir, fermented cottage cheese, kimchi and kombucha tea — for 10 weeks had lower markers of inflammation and improved diversity of microbes in their gut. Damman says that along with fiber, healthy fats and nutrients known as polyphenols found in plant-based foods, yogurt and other fermented foods are a staple of a healthy gut. "These are the common denominators across culinary traditions and healthy eating," he says. From Middle Eastern cream cheese-like labneh to Persian abdoogh khiar soup and Indian raita, cultures around the world have long embraced yogurt as a culinary staple. But before adding yogurt to your diet be sure to check the nutrition label. Research has found that, despite its health halo, many yogurts can be loaded with added sugar. Your best bet is to stick with yogurts without added sugar. Add some berries, bananas or other fruit if you miss that hint of sweetness. Heat compromises blood flow to the gut and leads to excessive sweating, which can cause dehydration, cramping, exhaustion and fainting. Muscle glycogen, the body's stored form of glucose, is used up more quickly when it is hot, impairing endurance performance, says Tipton. At his annual Super Bowl news conference Monday, NFL commissioner Roger Goodell strongly supported the league’s policies designed to promote diversity at the club-employment level and said they would continue. But during Super Bowl LIX, and with President Donald Trump apparently planning to attend on Sunday, the NFL might be making another kind of statement on the Caesars Superdome field itself. According to two league sources, who spoke on condition of anonymity because of the sensitivity of the discussions, league officials recently changed one of the slogans expected to be stenciled in the back of an end zone from “End Racism” to “Choose Love.” The game between the Kansas City Chiefs and the Philadelphia Eagles will mark the first time since February 2021 that “End Racism” is not included as a message in the back of a Super Bowl end zone. The switch, conveyed internally to high-level employees earlier this week, could be perceived as a nod to the current political climate. Following the lead of Trump, who was inaugurated last month, many corporations and institutions are abandoning their diversity, equity and inclusion programs. Goodell did not follow suit when asked about the league’s policies on Monday, saying he was “proud” of the league’s diversity efforts. “We got into diversity efforts because we felt it was the right thing for the National Football League,” Goodell said. “And we’re going to continue those efforts, because we’ve not only convinced ourselves we’ve proven it to ourselves — it does make the NFL better.” The decision to do away with “End Racism” as a slogan led at least one high-ranking league official to express concern in light of Trump’s public statements on the subject. But NFL spokesperson Brian McCarthy said that the decision was based on sensitivity to recent tragedies, including the terrorist attack in New Orleans’ French Quarter in January, the deadly wildfires in the Los Angeles area and the fatal air collision near Reagan National Airport near Washington, D.C. “It Takes All of Us” will also appear in the end zone for this year’s Super Bowl. “We felt it was an appropriate statement for what the country has collectively endured, given recent tragedies, and can serve as an inspiration,” said McCarthy, who noted that “Choose Love” and “It Takes All of Us” also appeared in the end zones for this year’s AFC Championship Game in Kansas City. The NFC Championship Game in Philadelphia included “End Racism” as an end-zone slogan. League sources also indicated that Trump is expected to attend Sunday’s game as a guest of New Orleans Saints owner Gayle Benson. The NFL launched its “Inspire Change” platform in 2018. Two years later, slogans such as “End Racism,” “It Takes All of Us,” “Stop Hate,” “Choose Love” and “Vote” began appearing on end-zone borders, part of a broader, multi-pronged effort to promote diversity and inclusion. In an internal memo at the time, the messages were said to demonstrate “how football and the NFL brings people together to work as one and use our example and our actions to help conquer racism.” Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki Icliki

But during Super Bowl LIX, and with President Donald Trump apparently planning to attend on Sunday, the NFL might be making another kind of statement on the Caesars Superdome field itself. According to two league sources, who spoke on condition of anonymity because of the sensitivity of the discussions, league officials recently changed one of the slogans expected to be stenciled in the back of an end zone from “End Racism” to “Choose Love.” The game between the Kansas City Chiefs and the Philadelphia Eagles will mark the first time since February 2021 that “End Racism” is not included as a message in the back of a Super Bowl end zone. The switch, conveyed internally to high-level employees earlier this week, could be perceived as a nod to the current political climate. Following the lead of Trump, who was inaugurated last month, many corporations and institutions are abandoning their diversity, equity and inclusion programs. Goodell did not follow suit when asked about the league’s policies on Monday, saying he was “proud” of the league’s diversity efforts. “We got into diversity efforts because we felt it was the right thing for the National Football League,” Goodell said. “And we’re going to continue those efforts, because we’ve not only convinced ourselves we’ve proven it to ourselves — it does make the NFL better.” The decision to do away with “End Racism” as a slogan led at least one high-ranking league official to express concern in light of Trump’s public statements on the subject. But NFL spokesperson Brian McCarthy said that the decision was based on sensitivity to recent tragedies, including the terrorist attack in New Orleans’ French Quarter in January, the deadly wildfires in the Los Angeles area and the fatal air collision near Reagan National Airport near Washington, D.C. “It Takes All of Us” will also appear in the end zone for this year’s Super Bowl. “We felt it was an appropriate statement for what the country has collectively endured, given recent tragedies, and can serve as an inspiration,” said McCarthy, who noted that “Choose Love” and “It Takes All of Us” also appeared in the end zones for this year’s AFC Championship Game in Kansas City. The NFC Championship Game in Philadelphia included “End Racism” as an end-zone slogan. League sources also indicated that Trump is expected to attend Sunday’s game as a guest of New Orleans Saints owner Gayle Benson. The NFL launched its “Inspire Change” platform in 2018. Two years later, slogans such as “End Racism,” “It Takes All of Us,” “Stop Hate,” “Choose Love” and “Vote” began appearing on end-zone borders, part of a broader, multi-pronged effort to promote diversity and inclusion. In an internal memo at the time, the messages were said to demonstrate “how football and the NFL brings people together to work as one and use our example and our actions to help conquer racism.” The changes were initiated in the wake of the murder of George Floyd, an unarmed Black man, by a Minneapolis police officer, sparking nationwide protests against police brutality. The issue had risen to the forefront of the NFL community four years earlier, when then-San Francisco 49ers quarterback Colin Kaepernick began kneeling during the national anthem, and other players around the league soon followed. t's not just athletes' physical performance that is diminished by heat, he adds. "Heat changes your cognitive function in terms of complex decision making, makes you more irritable and more agitated, reduces motivation, and decreases mood." This means that scorching temperatures can also impact more "passive sporting events'', such as archery or shooting, where the "margins of error are very small", he says. (Read more about the sinister ways heatwaves warp the mind.) Acclimatising to high temperatures is now a critical part of training for athletes, says Tipton. "If you get your heat preparation wrong, it's a risk to life and limb." Medal Moments Want to read more about the Olympics? Sign up for Medal Moments, your free global guide to Paris 2024, delivered daily to your inbox throughout the Games. Mohan is preparing for high temperatures at the Paris Olympics by spending up to an hour in saunas several times a week and turning off the fans while doing her indoor cycling training. "Being an outdoor sport, whatever conditions you can think of, we have trained in them," says Pritchard. Organisers say they are taking a number of precautions to protect athletes from extreme heat. Outdoor endurance events such as the marathon and triathlon will start early, at 8am, when it is cooler, and athletes will have access to water stations and shaded areas at regular intervals, says Lambis Konstantinidis, executive director of planning and coordination at the Paris Olympics. The triathlon will be postponed if the temperature rises above 32.2C (90F), in them – Benjamin Pritchard Some delegations, including the US, have said that they plan to bring their own air-conditioning units, for athletes' rooms. "In our conversations with athletes, this was a very high priority and something that the athletes felt was a critical component in their performance capability," Sarah Hirshland, chief executive of the Olympic and Paralympic Committee leadership committee, said during a press briefing in June. Healthy eating during pregnancy and the year after giving birth may be uncommon in the United States, suggests a study by researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and other institutions. On a scale from “A” to “F,” study participants received a grade of “D” on a measure of healthy eating. However, eating habits remained stable during pregnancy and after, with scores changing little during the six times participants were questioned during the study. The authors concluded that their results suggest a need to improve diet quality during and after pregnancy. more more more more more more more more more more more more more more more more more more more more more more The study was conducted by Leah Lipsky, Ph.D., of the NICHKonstantinidis says. The AC question In a bid to halve the carbon footprint of the Paris Olympics compared with previous games, air conditioning units have not been installed in the Olympic Village. Instead, the village will be cooled by a geothermal system which pumps water from deep below the ground to keep indoor temperatures 6C (10.8F) lower than outside, according to the organising committee. More than 9,000 trees have also been planted in the Olympic and Paralympic villages to provide natural cooling. The "natural freshness" of the River Seine will also help cool the city centre, says Konstantinidis. Whatever conditions you can think of, we have trained D Social and Behavioral Sciences Branch, and colleagues. It appears in the American Journal of Clinical Nutrition. Background Nutrition during and after pregnancy is important for the health of the parent and child. Research suggests that during and after pregnancy, most individuals consume too much fat and sugar and not enough fiber, vitamins, and minerals. However, few studies have assessed overall diet quality during and after pregnancy. Information on diet quality during and after pregnancy is needed to identify those at risk for inadequate nutrition and to develop interventions to help them. Results For the current study, researchers analyzed data from 383 participants in a previous study. During study visits, participants in a North Carolina health care system provided information on what they ate for the previous day during the first, second, and third trimesters of pregnancy and at 6 weeks, 6 months, and 12 months after giving birth.

Healthy eating during pregnancy and the year after giving birth may be uncommon in the United States, suggests a study by researchers at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and other institutions. On a scale from “A” to “F,” study participants received a grade of “D” on a measure of healthy eating. However, eating habits remained stable during pregnancy and after, with scores changing little during the six times participants were questioned during the study. The authors concluded that their results suggest a need to improve diet quality during and after pregnancy. The study was conducted by Leah Lipsky, Ph.D., of the NICHD Social and Behavioral Sciences Branch, and colleagues. It appears in the American Journal of Clinical Nutrition. Background Nutrition during and after pregnancy is important for the health of the parent and child. Research suggests that during and after pregnancy, most individuals consume too much fat and sugar and not enough fiber, vitamins, and minerals. However, few studies have assessed overall diet quality during and after pregnancy. Information on diet quality during and after pregnancy is needed to identify those at risk for inadequate nutrition and to develop interventions to help them. Results For the current study, researchers analyzed data from 383 participants in a previous study. During study visits, participants in a North Carolina health care system provided information on what they ate for the previous day during the first, second, and third trimesters of pregnancy and at 6 weeks, 6 months, and 12 months after giving birth. Researchers scored participant responses according to the Healthy Eating Index, a measure of how closely someone’s diet adheres to the Dietary Guidelines for Americans. The Healthy Eating Index gauges consumption of healthy foods such as fruit, vegetables, greens, legumes, and whole grains, as well as foods that should be consumed in moderation, such as refined grains, sodium, added sugars, and saturated fats. Healthy Eating Index scores range from 0 to 100 and are expressed in a graded approach, with 90 to 100 equivalent to an A, 80 to 89 equivalent to a B, 70 to 79 a C, and 60 to 69 a D. The group’s average was 61.4 during pregnancy and 61.7 in the year after pregnancy—both low Ds. The highest scores were seen in participants with a college degree (64.7 in pregnancy and 66.4 post pregnancy) and among non-Hispanic whites (64.7 in pregnancy and 66.4 post pregnancy). Participants’ scores were consistent throughout the study, with only minor variations between visits. Significance The authors noted that low diet quality scores were present among all groups in the study, which reflects an urgent need for widespread improvement. First the Baltics, now Taiwan. This month saw the latest in a spate of incidents in which crucial undersea cables connecting U.S. allies have been damaged or severed. Some have been cast as acts of sabotage, pinning blame on Russia and China amid heightened geopolitical tensions. Early this month, Taiwan’s coast guard said it had intercepted the Xing Shun 39 — a Hong Kong-owned freighter carrying the Cameroonian and Tanzanian flags — after the Beijing-claimed island’s biggest telecom company, Chunghwa Telecom, alerted authorities that an international undersea cable had been damaged on Jan. 3. A “preliminary assessment” suggested the damage might have been caused by the freighter, which “transited the area at the time of the incident,” the coast guard said. more more more more more more more more more more more more more more more more more more more With an average of about 200 cable faults a year, according to the International Cable Protection Committee, damage to undersea communications infrastructure is not uncommon. The majority is caused by ship anchors or fishing activity such as trawling, where heavy equipment is dragged across the seafloor. But the Taiwanese government says this may have been an example of Chinese “gray-zone interference,” irregular military and non-military tactics that aim to wear down an opponent without engaging in an actual shooting war. It also comes amid an uproar in Europe, where NATO is stepping up patrols of Baltic Sea cables that provide power and enable almost all intercontinental communication, including the internet. In Helsinki on Tuesday, members of the defense bloc with access to the Baltic Sea agreed at a summit discussing regional security threats — including Russian cable sabotage — to deploy frigates, patrol aircraft and naval drones in the Baltic Sea to help protect critical infrastructure.

But during Super Bowl LIX, and with President Donald Trump apparently planning to attend on Sunday, the NFL might be making another kind of statement on the Caesars Superdome field itself. According to two league sources, who spoke on condition of anonymity because of the sensitivity of the discussions, league officials recently changed one of the slogans expected to be stenciled in the back of an end zone from “End Racism” to “Choose Love.” The game between the Kansas City Chiefs and the Philadelphia Eagles will mark the first time since February 2021 that “End Racism” is not included as a message in the back of a Super Bowl end zone. The switch, conveyed internally to high-level employees earlier this week, could be perceived as a nod to the current political climate. Following the lead of Trump, who was inaugurated last month, many corporations and institutions are abandoning their diversity, equity and inclusion programs. Goodell did not follow suit when asked about the league’s policies on Monday, saying he was “proud” of the league’s diversity efforts. “We got into diversity efforts because we felt it was the right thing for the National Football League,” Goodell said. “And we’re going to continue those efforts, because we’ve not only convinced ourselves we’ve proven it to ourselves — it does make the NFL better.” The decision to do away with “End Racism” as a slogan led at least one high-ranking league official to express concern in light of Trump’s public statements on the subject. But NFL spokesperson Brian McCarthy said that the decision was based on sensitivity to recent tragedies, including the terrorist attack in New Orleans’ French Quarter in January, the deadly wildfires in the Los Angeles area and the fatal air collision near Reagan National Airport near Washington, D.C. “It Takes All of Us” will also appear in the end zone for this year’s Super Bowl. more more more more more more more more more more more more more more more more more more more

All seven crew members aboard the freighter were Chinese nationals, the Taiwan coast guard said. It said the ship was owned by a Hong Kong company called Jie Yang Trading, which according to public records was incorporated in 2020. Its Chinese-national director, Guo Wenjie, denied that his ship was responsible for the damage, saying “there’s no evidence at all.” “I spoke to the ship captain and for us it was a normal trip,” he told Reuters. NBC News was unable to reach Guo. Taiwan’s suspicion toward Beijing stems in part from a 2023 incident in which the 14,000 people who live on the Taiwan-controlled Matsu islands, which sit close to the Chinese mainland, were disconnected from the internet after two undersea cables connecting the islands were cut. At the time, authorities said a Chinese fishing vessel and freighter had damaged the cables, but said there was no evidence that it was deliberate. The same year, another Chinese ship called NewNew Polar Bear damaged a gas pipeline between Estonia and Finland. It took months for Beijing to admit that its ship was responsible, saying it was an accident. “What this has done in recent years is expose the vulnerability of these cables that have been out of sight, out of mind,” Parr said. Analysis included in the Rings of Fire report shows that in the past 100 years there has been a significant increase in the number of "tropical" nights, when temperatures do not drop below 20C (68F). Between 1924 and 1933, only four tropical nights were observed in Paris. In 2014-2023, the city experienced a total of 84 tropical nights – 21 times more. Mohan says she has "mixed feelings" about the lack of air conditioning in the village. She says she understands organisers' commitment to sustainability but is worried about the impact heat will have on her health and recovery following the triathlon. "Recovery is very important for athletes," she says. "I want to be safe. I don't want to come back injured and I don't want to not have my best performance on the day." The organisers of the games have said that Paralympic delegations will be provided with one free air-conditioning unit for every three athletes for medical reasons, as some athletes experience thermoregulation problems. It's difficult to know exactly how polluted Parisian air was in 1924, when air quality monitoring was in its infancy. There are some records dating back to the early 20th Century, such as measurements of suspended dust from industrial processes or measurements of atmospheric electricity. The Eiffel Tower was an ideal structure for taking these measurements and scientists have used these records to infer smoke pollution levels in the French capital in the 1890s. more more more more more more more more more more more more more more more more more more more more